Category: CRISPR

The global healthcare landscape is facing an unprecedented challenge with antimicrobial resistance (AMR), posing a significant threat to our ability to combat bacterial infections effectively. CRISPR-Cas systems have emerged as a promising tool in the fight against AMR, offering precise genetic modifications to target and eliminate antibiotic-resistant genes. In this review, we delve into the […]

In the realm of biotech investments, where science intertwines with financial prospects, a strategic approach is essential to navigate the complex landscape of clinical trials, regulatory expectations, and patient recruitment challenges. The allure of genome editing and gene therapy beckons to those seeking substantial growth potential, promising innovative treatments for previously untreatable genetic disorders. As […]

Creative Biolabs is at the forefront of revolutionizing gene therapy research through the utilization of advanced CRISPR screening platforms. These cutting-edge tools empower researchers to delve deep into the world of genetics, unraveling the complexities of gene function, regulation, and interaction. As the field of gene therapy continues to evolve and reshape the landscape of […]

In the fast-paced world of cutting-edge biotech, the story of KJ Muldoon stands out as a beacon of hope and innovation. Born with a rare single-gene mutation that put his life in jeopardy, KJ’s journey to receiving the world’s first personalized mRNA-based CRISPR therapy was nothing short of miraculous. The key to this groundbreaking treatment? […]

Tuberculosis, a disease affecting over 10 million individuals annually, faces a significant challenge – about 40% of cases remain undiagnosed. This critical gap in detection arises from the limitations of sputum-based testing, which many patients, especially those without symptoms, struggle to provide. Additionally, collecting sputum in low-resource settings poses a significant challenge. To address these […]

In a groundbreaking development in the fight against tuberculosis, researchers have unveiled a potential game-changer: the ability to screen for this deadly infectious disease using a simple mouth swab rather than the traditional sputum testing method. This innovative approach, leveraging advanced CRISPR-based technology, has the potential to revolutionize tuberculosis screening, offering a more accessible and […]

Ahoy, science enthusiasts! Today we set sail on an exciting voyage through the world of gene editing in hard corals, specifically focusing on the magnificent Astrangia poculata. Strap on your lab goggles and get ready to dive deep into the realm of microinjection, gene knockdown, and CRISPR-mediated gene knock-in as we explore the cutting-edge research […]

In the intricate dance of early embryonic development, the process of neurulation stands out as a pivotal moment where a flat sheet of neural cells transforms into the neural tube, the precursor to the brain and spinal cord. The significance of understanding this metamorphosis, crucial for the prevention of devastating birth defects like spina bifida, […]

The study combines microscopy and CRISPR screening to identify factors influencing global chromatin organization, focusing on centromere clustering as a proxy. By targeting 1064 genes, key regulators of spatial centromere organization were uncovered, revealing associations with nucleolus, kinetochore, cohesins, condensins, and nuclear pore complex components. Alterations in centromere distribution were linked to mitotic progression, highlighting […]

Prime editing, a cutting-edge CRISPR/Cas-based genome editing technique, has rapidly evolved with novel applications and improved versions, necessitating ongoing analysis and enhancement. This review explores the prime editing mechanism, optimization strategies, and the potential future of CRISPR/Cas9-associated genome editing. At the core of prime editing is a prime editor fusion protein, comprising a nickase and […]

At the WIRED Health summit that took place in Boston on September 9, industry-leading experts gathered to delve into groundbreaking discussions on topics such as Crispr, whole-genome sequencing, cancer vaccines, and more. Even if you missed the event, you can still catch up on the insightful conversations and keynotes online. From luminaries like David Liu, […]

In the realm of genome editing, the CRISPR-Cas system has revolutionized the way we approach gene manipulation, offering a precise and efficient tool for editing DNA sequences. The discovery of the CRISPR-Cpf1 system, a variation of the CRISPR-Cas system, has further expanded the possibilities for genome editing. However, despite its unique features such as smaller […]

In the intricate realm of biological processes, the ability to capture and understand the dynamics of cellular events over time holds immense potential. While our knowledge of biological signals and regulatory programs continues to expand, the challenge of accurately profiling time-varying biological signals remains a daunting task. The development of a novel framework to encode […]

At the recent WIRED Health Summit, David Liu, a prominent biochemist and pioneer in gene editing from Harvard, announced a groundbreaking concept that could potentially revolutionize the field of genetic medicine. Referred to as disease-agnostic therapeutic gene editing, this innovative strategy aims to develop a single gene-editing approach capable of treating a wide range of […]

Phage therapy, a method utilizing bacteriophages to combat bacterial infections, has reemerged due to escalating antibiotic resistance concerns. While phages are currently selected mainly based on simplistic criteria, there is a growing interest in exploring whether phages can evolve within a host to improve treatment efficacy. Mathematical and computational models are employed to investigate this […]

In the intricate dance of evolution, pathogens and their hosts engage in a constant arms race, each adapting to outwit the other. Pathogens vary in their virulence, the harm they inflict on their hosts, which in turn drives the selection pressure on the hosts to evolve resistance mechanisms. While the evolution of virulence in pathogens […]

Welcome to the realm of high-throughput screening, a domain where groundbreaking advancements in biological and chemical assays are unveiled through the lens of efficiency, speed, and precision. Delving into the array of articles curated from the prestigious Nature Portfolio, we embark on a journey through cutting-edge methodologies and discoveries that redefine the boundaries of scientific […]

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells revolutionizes the functional genomics landscape. The study showcases the potential of CRISPR technology to systematically interrogate gene function on a genome-wide scale. By delivering a genome-scale CRISPR-Cas9 knockout (GeCKO) library targeting over 18,000 genes with 64,000 unique guide sequences, both negative and positive selection screenings in human cells […]

Genetic disorders have long been the focus of medical research, with treatments typically centered around managing symptoms. However, a groundbreaking discovery in February 2025 by researchers from Mie University in Japan has opened up a new realm of possibilities by targeting the root cause of genetic conditions through gene editing. This innovative approach involves the […]

In the realm of genome editing, CRISPR RNA-guided nucleases (RGNs) have emerged as versatile tools with immense potential for both research and clinical applications. However, a critical challenge in harnessing the full potential of these tools lies in understanding and mitigating their off-target effects. The ability to accurately delineate genome-wide off-target cleavage activities of CRISPR-Cas […]

In the realm of cutting-edge bioengineering, the field of organoid research has been revolutionized by recent advances in 3D cell culture technology. This breakthrough has allowed scientists to create stem cell-derived organoids that closely mimic the structure and function of native organs. The quest for understanding the essential factors controlling organoid development has led to […]

The CRISPR Screen LabTech platform stands as a beacon of scientific expertise, offering a cutting-edge functional genomic screening platform utilizing CRISPR-Cas9 technology. Established to support local, regional, and national CRISPR screening initiatives, this platform plays a pivotal role in assisting researchers in screen design, operational support during assay execution, and data analysis. Beyond the realm […]

In the realm of cancer treatment, the emergence of immunotherapy has brought forth a new era of hope and possibilities. Despite its promising outcomes, challenges such as immune evasion mechanisms of tumour cells, immunosuppressive tumour microenvironments, and antigen delivery limitations have hindered the full potential of immunotherapy. Enter CRISPR/Cas9 gene editing technology, a precise tool […]

In the dynamic landscape of gene therapy, lentiviral vectors (LVs) have emerged as indispensable tools for delivering genetic material into target cells. The escalating demand for LVs necessitates continuous advancements in production methods to enhance titers, optimize yields, reduce costs, and ensure product safety. Amidst these advancements, a significant challenge known as retro-transduction has surfaced, […]

Breakfast cereal, packaged snacks, and sugary drinks have long been staples in many households, often viewed as harmless treats when consumed in moderation. However, a groundbreaking study published in Neurology, the journal of the American Academy of Neurology, on May 7, 2025, has shed light on a potential link between the overconsumption of highly processed […]

ToolGen, a prominent player in gene editing technology, recently made headlines by initiating a patent infringement lawsuit against Lonza Netherlands BV in the Hague District Court in the Netherlands. This legal action stems from Lonza’s alleged unauthorized use of ToolGen’s CRISPR Cas9 RNP source technology in the production of ‘Caszevi,’ a groundbreaking gene editing treatment […]

Sleep is a fundamental aspect of our lives, yet its intricacies have long evaded full comprehension. The release of growth hormone during sleep has been recognized for its role in facilitating muscle and bone growth while reducing fat. However, the precise mechanisms governing this process have remained shrouded in mystery. Recent research spearheaded by Yang […]

In the realm of medical research, the pursuit of tailored therapies has taken a significant leap forward with the recent milestone of administering personalized CRISPR therapy to the first patient, Baby KJ. Baby KJ, born with a rare genetic metabolic disorder that posed severe health risks, underwent a transformative personalized CRISPR treatment that defied initial […]

Crispr gene-editing technology has shown promise in various fields, including the treatment of rare diseases, climate-resilient crop development, and even altering the characteristics of organisms like spiders. The potential of Crispr to revolutionize healthcare by finding a cure for global diseases like diabetes is significant. A recent study has made a breakthrough by implanting Crispr-edited […]

In a groundbreaking development, a type 1 diabetes patient has achieved a remarkable milestone by generating his own insulin through a cutting-edge procedure involving CRISPR-edited cells. Unlike type 2 diabetes, which is more common, type 1 diabetes is an autoimmune condition where the body’s immune system mistakenly attacks and destroys insulin-producing islet cells in the […]

Regeneron Pharmaceuticals, a company focused on discovering, developing, and commercializing products to combat various diseases, has been under the scrutiny of 15 analysts over the past quarter. Analyst ratings for Regeneron Pharmaceuticals have ranged from bullish to bearish, providing insights into the evolving sentiments surrounding the company. Recent data reveals an average 12-month price target […]

Stem cells play a crucial role in the body, giving rise to all cell types. However, genetic mutations and aging can impair their functionality, reducing the body’s ability to repair damaged tissues or replace dysfunctional cells. Stem cell therapies hold promise in harnessing the regenerative potential of stem cells to treat various diseases and injuries […]

In a groundbreaking development in the field of xenotransplantation, a gene-edited pig lung has been successfully transplanted into a brain-dead patient in China. This significant milestone represents a crucial step towards potentially addressing the critical shortage of donor lungs for transplant patients worldwide. The groundbreaking experiment aimed to assess the feasibility of utilizing pigs that […]

The CRISPR-Cas system, a bacterial defense mechanism against phages, has revolutionized genetic engineering. Among its many components, the Cas13d enzyme stands out for its ability to target RNA exclusively, making it a promising tool for transcriptome engineering. A recent study delved into the structural basis of Cas13d function, shedding light on its RNA-guided ribonuclease activity. […]

CRISPR-Cas systems have revolutionized genetic engineering by enabling precise control over gene expression. In bacteria, CRISPR activation (CRISPRa) is a powerful tool for regulating gene networks. However, traditional CRISPRa methods are limited by stringent target site requirements, particularly the presence of a specific protospacer adjacent motif (PAM). To overcome this limitation, researchers have developed PAM-flexible […]

Base editing technologies have revolutionized the field of genetic engineering by offering precise and efficient methods for modifying DNA sequences. These technologies, such as Zinc-finger, Transcription Activator-like Effector, and CRISPR/Cas-based gene editing, provide integrated services for disrupting, adding, and correcting genes in cells and organisms. With a comprehensive service catalog including delivery systems, gene editing […]

Phages, viruses that infect bacteria, play a vital role in shaping microbial communities, impacting human health. Bacteria have various defense mechanisms against phages, such as mutating phage receptors or utilizing CRISPR-Cas adaptive immunity. However, the interactions between phages and these defense mechanisms and their effects on microbial communities remain poorly understood. A recent study conducted […]

The CRISPR/Cas9 system, known for its programmability and specificity in gene editing, faces challenges due to structural and stability alterations in the genome. The transition from Cas9 to dCas9, lacking endonuclease activity but retaining DNA binding ability, has paved the way for the development of CRISPRa and CRISPRi tools. These tools, by modifying chromosomal elements, […]

Synthetic lethality in cancer therapy involves targeting gene interactions that are lethal only when both genes are dysfunctional, providing a promising avenue for personalized and precise treatments. Tumor cells often acquire mutations in DNA repair pathways, leading to resistance to traditional therapies. By identifying synthetically lethal gene pairs, researchers aim to selectively target cancer cells […]

Type 1 diabetes, an autoimmune disorder where the body attacks insulin-producing cells, is a prevalent condition requiring continuous management. While gene-altering therapies like CRISPR-Cas9 show promise, they are not the standard treatment for newly diagnosed patients. Stem cell transplants and pancreas transplants are also under study but are currently reserved for cases where standard treatments […]

University of Florida (UF) researchers are pioneering a groundbreaking approach to enhance organ transplant procedures, likening their innovative research to a dishwasher for human organs awaiting transplantation. This transformative technology, spearheaded by UF researchers, aims to optimize the condition of organs pre-transplantation, ultimately leading to healthier outcomes for recipients. The collaborative efforts between UF researchers […]

CRISPR/Cas9 technology has revolutionized gene therapy by offering a precise and efficient method of DNA editing. However, the challenge lies in developing safe and effective delivery systems for CRISPR/Cas9 constructs to target specific genes without causing off-target effects. Nanoparticles (NPs) have emerged as a promising solution to address this challenge by efficiently delivering CRISPR-Cas9 elements […]

The Wellcome Sanger Institute in Cambridge stands out as a unique hub for genomic research, emphasizing collaboration, innovation, and individual support. This institute focuses on delivering groundbreaking science to address some of humanity’s most significant challenges through its visionary and creative approach at scale. By fostering a community of top-tier professionals and thinkers, the Institute […]

Clustered regularly interspaced short palindromic repeats (CRISPR)-based therapeutics are gaining traction as a novel approach to combat infectious diseases amidst the rise of antimicrobial resistance (AMR) and the lack of curative treatments for chronic viral infections such as human immunodeficiency virus (HIV) and herpes. Recent reports, like GlobalData’s CRISPR Gene Editing in Infectious Diseases: Market […]

In the realm of infectious diseases, the rise of antimicrobial resistance (AMR) and the lack of curative treatments for chronic viral infections like HIV and herpes have spurred the exploration of innovative therapeutic approaches. Among these, clustered regularly interspaced short palindromic repeats (CRISPR)-based therapies are gaining traction as a promising strategy. Key opinion leaders (KOLs) […]

CRISPR Therapeutics, a prominent biotech company, achieved a significant milestone with its first approved therapy, Casgevy, designed for sickle cell disease and transfusion-dependent beta-thalassemia. This marked a crucial advancement in the field of gene editing, especially as it was developed in collaboration with Vertex Pharmaceuticals, showcasing the viability of CRISPR Therapeutics’ strategic approach. Despite facing […]

In the realm of infectious diseases, where challenges like antimicrobial resistance (AMR) and the lack of curative treatments for chronic viral infections persist, a new ray of hope emerges in the form of clustered regularly interspaced short palindromic repeats (CRISPR)-based therapeutics. These innovative therapies are revolutionizing the field by targeting latent viral reservoirs and drug-resistant […]

The gastrointestinal tract of mammals harbors a diverse and abundant microbial community known as the gut microbiota. This microbiota plays a crucial role in providing the host with beneficial functions like colonization resistance, nutrient metabolism, and immune tolerance. Disruption of this delicate balance, termed dysbiosis, can lead to various adverse health outcomes such as neurological […]

The global Mice Model Market, valued at US$1.53 billion in 2024, is anticipated to reach US$2.74 billion by 2030, representing a robust CAGR of 10.0% during 2025-2030. This growth trajectory is fueled by factors such as the increasing adoption of mice models in preclinical studies, rising demand for personalized medicine in oncology, and advancements in […]

CRISPR Therapeutics AG recently released its second-quarter 2025 financial results, revealing a revenue increase from US$517,000 to US$892,000 compared to the previous year. However, the company also reported a noteworthy rise in net loss from US$126.41 million to US$208.55 million during the same period. The substantial widening of the net loss per share raises questions […]

Pairwise, a Durham-based agtech startup, has secured a significant partnership with Mars Inc., a renowned confectionery and food company, to utilize its CRISPR gene editing platform, Fulcrum, for enhancing cacao production. This collaboration aims to leverage CRISPR technology to bolster crop resilience, adaptability to climate challenges, and disease resistance in cacao plants, which are crucial […]

In a bid to safeguard cocoa production from the looming threats of climate change, Mars Inc., a leading confectionery player, has joined forces with biotech company Pairwise. Together, they are delving into the realm of gene editing, particularly leveraging CRISPR technology, to fortify cocoa crops against environmental challenges. CRISPR, short for Clustered Regularly Interspaced Short […]

Researchers at the Salk Institute for Biological Studies have identified a promising avenue for the development of new obesity drugs by delving into the realm of microproteins, small proteins derived from previously overlooked portions of DNA. These microproteins, typically less than 100 amino acids long, can play crucial roles in regulating various biological processes, from […]

The exploration of the deep-sea realm has unveiled two novel marine actinobacterial strains, MA3_2.13 and S07_1.15, isolated from the depths of the Madeira archipelago in the NE Atlantic Ocean. By employing a hybrid sequencing strategy combining Illumina and PacBio technologies, the genomes of these isolates were de novo assembled, revealing intriguing insights into their biosynthetic […]

Over the past twenty-five years, the Valencian Community has emerged as a prominent scientific hub in Spain and Southern Europe, achieving significant milestones in various fields such as biomedicine, neuroscience, and molecular chemistry. Through a dynamic network of universities, cutting-edge research institutes, and expanding infrastructures, the region has made notable progress in technological innovation, particularly […]

Clustered regularly interspaced short palindromic repeats (CRISPR) technology has revolutionized gene editing, offering vast applications in genetic research across various organisms and industries. This study focuses on integrating CRISPR-Cas9 and homology directed repair (HDR) techniques to edit two known genes in Saccharomyces cerevisiae, namely Adenine2 (ADE2) and Sterile12 (STE12). These genes influence metabolic and developmental […]

Antimicrobial resistance (AMR) poses a significant threat to global health, fueled by the diverse and mobile nature of antimicrobial resistance genes (ARGs). Horizontal gene transfer (HGT) mechanisms, like conjugation, transduction, and transformation, enable the spread of ARGs among bacteria, leading to multidrug resistance. Plasmids, a type of mobile genetic element (MGE), play a central role […]

Snickers maker Mars has announced its partnership with Pairwise, a plant-breeding technology company, to implement gene-editing techniques aimed at enhancing cocoa production. This move comes in response to the challenges faced by the chocolate industry due to climate change and diseases impacting cocoa crops, leading to a global cocoa shortage. The soaring costs associated with […]

In recent years, the field of biotechnology has witnessed a remarkable surge in the development and utilization of home testing kits. Among these innovative products, the Podolia CRISPR home testing kits have garnered significant attention for their potential to revolutionize genetic testing and diagnostics. These kits leverage the power of CRISPR-Cas9 technology, a groundbreaking genome […]

Stem cells have long been known for their remarkable regenerative abilities across various species, from axolotls to zebrafish. While humans possess the potential for using stem cells in treating a wide array of conditions, the field is continuously evolving with the emergence of more physiologically relevant stem cell assays. The three primary categories of human […]

Mars Inc. has embarked on a strategic move to leverage gene-editing technology to expedite the development of more resilient cocoa plants, aiming to secure a stable supply of this vital crop. By partnering with Pairwise, an agricultural gene editing company, Mars gains access to advanced CRISPR tools that enable precise modifications to organisms’ DNA sequences. […]

CRISPR-Cas technology has revolutionized molecular diagnostics by enabling the detection of single-nucleotide mutations. A novel photocontrolled one-pot assay combining recombinase polymerase amplification (RPA) with CRISPR-Cas12a was developed for the rapid identification of SARS-CoV-2 Omicron variants. This innovative system overcomes the limitations of traditional one-pot assays by using a photocleavable p-RNA to prevent premature Cas12a activation […]

In the realm of biological molecules, RNA often takes a backseat to its more renowned counterpart, DNA. While DNA is recognized for its pivotal role in providing genetic instructions for protein synthesis, recent studies have shed light on the critical involvement of RNA-binding proteins in regulating RNA’s messages. Mutations in genes encoding RNA-associated proteins have […]

As the field of biotechnology advances, single-cell CRISPR technology has emerged as a powerful tool in gene editing and molecular biology research. This technology allows for precise manipulation of individual cells, offering unprecedented insights into cellular functions and disease mechanisms. Companies like CRISPR Therapeutics are at the forefront, providing innovative solutions such as CRISPRCas9 CellLine […]

Intellia Therapeutics, a prominent player in the field of regenerative medicine and biotechnology, boasts a cutting-edge modular CRISPR/Cas9 gene editing platform designed for the treatment of various diseases. This platform presents a massive opportunity in the realm of CRISPR technology, with the company at the forefront of innovative breakthroughs and catalysts in the field. Through […]