Category: Bioreactor

Algae, typically found in oceans and lakes, are now making a splash in the world of carbon capture technology. These versatile organisms have the unique ability to consume carbon dioxide during photosynthesis, presenting a promising solution for reducing pollution and combating climate change, especially in industries like coal-fired power plants. One company at the forefront […]

In the realm of biopharmaceuticals, the utilization of single-use bioreactor bags presents a unique challenge in facing extractables and leachables (E&L). These plastic-based systems harbor vulnerabilities that can impact product quality and efficacy. Delving into a roundtable discussion with industry experts sheds light on the complexities involved in mitigating these risks and troubleshooting potential issues […]

Aerobic bioprocesses rely heavily on the oxygen transfer rate (OTR) from sparged to dissolved gas. Given the low solubility of oxygen, the choice of mixer impeller configuration plays a crucial role in the design of a bioreactor vessel. This article delves into a series of experiments and computational fluid dynamics (CFD) simulations to elucidate how […]

Your body’s hematopoietic stem cells (HSC) are the diligent managers responsible for orchestrating the production of blood cells in times of need. However, when faced with prolonged stressors like infection or injury, these stem cells can age prematurely, losing their vitality and efficiency over time. The intriguing twist comes when envisioning these essential cellular managers […]

In the realm of biopharmaceutical innovation, where the dance of science meets the rhythm of regulatory expectations, the applications of off-gas mass spectrometry in fed-batch mammalian cell culture emerge as a seductive tango of precision and insight. Imagine a world where the very breath of cells is analyzed, revealing the metabolic secrets hidden within the […]

Welcome to the exciting world of microbioreactor systems, where growth rates are determined with finesse and precision. Today, we delve into the realm of automated growth rate determination in high-throughput microbioreactor systems, unlocking the secrets of real-time biomass estimation in microbial reactors. This captivating journey will take us through the intricacies of biological fitness metrics […]

In this research demonstration, the focus was on utilizing spheroids from the β-TC6 insulinoma cell line to showcase the significance of regulating nutrient levels in enhancing cell yields. The study highlighted the importance of continuous feeding systems in comparison to batch feedings, especially in overcoming limitations in key nutrients such as glucose, which can hinder […]

Welcome to the latest scoop on industrial water management! Today, we are thrilled to share the exciting news that Dr. Graham Juby, Vice President at Carollo Engineers, the leading water engineering and consulting firm in North America, has been honored as a Fellow of the Water Environment Federation (WEF). This prestigious accolade acknowledges Dr. Juby’s […]

Bioreactors play a crucial role in tissue engineering by providing a controlled environment for cell cultures, facilitating nutrient exchange and waste removal. However, the diversity in bioreactor designs and stimulation protocols has posed challenges in standardization and reproducibility. To address this, a groundbreaking open-source 3D printable perfusion bioreactor, named JANUS, coupled with a numerical model-driven […]

In the realm of biotechnology, the investigation of human gut microbiota dynamics is a critical area of study. The impact of molecules on gut microbiota composition and function can be studied in vitro without the host’s implications. However, existing models like the Simulator of Human Intestinal Microbial Ecosystem (SHIME®) are costly, time-consuming, and require specialized […]

At the forefront of innovation, the University of California, Davis has embarked on a groundbreaking journey fueled by a $3 million National Science Foundation grant. This initiative aims to revolutionize plant biomanufacturing, paving the way for sustainable production in low-resource environments on Earth and beyond, into the realms of space exploration. Led by distinguished experts […]

In the realm of biotech manufacturing, the industrialization of stem-cell based therapies presents a unique set of challenges. The gap between research and commercialization necessitates scalable cell production platforms to meet the demand for therapeutic cell types. Human pluripotent stem cells (hPSCs) serve as a crucial source material for generating these therapeutic cells, requiring innovative […]

In the realm of biotechnology, a formidable challenge looms over the efficiency and productivity of bioconversion processes – the oxygen transferring rate (OTR). This critical parameter plays a pivotal role in the success of high-density biocatalyst systems, affecting everything from mass transfer to foaming issues. Ultrahigh-titer bioconversions are often hindered by the limitations in oxygen […]

In the realm of food science and agriculture, a groundbreaking innovation has emerged – protein powder made out of air. This revolutionary approach not only addresses the pressing issue of environmental impact due to traditional food production but also offers a sustainable solution to feeding the world’s growing population. The protein powder, developed by scientists […]

Microbial fermentation processes are at the heart of modern bioprocessing, driving towards higher production yields and efficiency. To achieve these goals, high-throughput screening and optimization of microbial strains are essential. Traditionally, such screenings have been carried out using slow and labor-intensive methods like submerged cultivation in shake flasks or microtiter plates. However, these methods have […]

In the realm of food science and agriculture, a groundbreaking innovation is taking center stage, offering a glimmer of hope for a more sustainable future. Enter Solar Foods, a Finnish startup leading the charge in transforming air and electricity into a revolutionary protein powder. This innovative approach not only holds the potential to reshape global […]

Katie Kam, a proud Texan and the visionary behind BioBQ, is on a mission to introduce lab-grown barbecue brisket to the Lone Star State. With a deep-rooted passion for sustainable food sources and a commitment to environmental resilience, Katie is determined to pave the way for cultured meat despite opposition from certain Texas lawmakers. As […]

Cellular Agriculture Ltd, a pioneering UK-based company, is making waves in the cultivated food sector with its recent strategic moves and groundbreaking bioreactor systems. By enhancing its infrastructure, forging new partnerships, and setting the stage for large-scale production, the company is solidifying its position as a key player in the biopharma and cell culture industries. […]

Plants have been a fundamental part of human civilization, providing sustenance, medicine, and materials for various industries. The advent of plant cells in bioreactors marks a significant milestone in biotechnology, offering a novel approach to obtaining valuable products from plants. Through advancements in recombinant DNA technologies, the potential to produce exogenous molecules in plants has […]

Microcarrier-based cultures have revolutionized the landscape of scalable cell culture, spanning diverse applications from vaccine production to cell therapy and even cultured meat. These systems typically traverse attachment, growth, and detachment phases, each crucial for successful cell expansion and harvesting. In the realm of biopharmaceuticals and regenerative medicine, monitoring viable cell density (VCD) through capacitance […]

In the realm of biomanufacturing, the potential impact of mycoplasma contamination events on Chinese hamster ovary (CHO) cell bioreactor cultures is a critical focal point. Mycoplasma, part of the Mollicutes genus, present unique challenges due to their small size and elusive nature. These bacteria, lacking a cell wall, can easily infiltrate sterilizing-grade filters and contaminate […]

Fermentation pH plays a crucial role in the physiological dynamics of microorganisms like Lactobacillus bulgaricus CFL1 during controlled cultures. This study focuses on elucidating how fermentation pH, particularly at pH 6 and pH 5, influences the cellular state of L. bulgaricus CFL1, with implications for starter production and fermented product quality. By examining parameters such […]

Scientists at the Massachusetts Institute of Technology (MIT) have broken new ground by introducing the first-ever publicly accessible model designed to forecast the long-term stability of Chinese Hamster Ovary (CHO) cells, a widely utilized cell type in biotherapeutic manufacturing. Spearheaded by Pedro Seber e Silva, a PhD candidate in the MIT School of Engineering, this […]

A breakthrough large-scale production platform has been unveiled by researchers at Allife Medicine and Peking University for generating consistent, high-quality extracellular vesicles (EVs) from induced mesenchymal stem cells (iMSCs). Overcoming challenges like limited expansion capacity, phenotypic variations, and batch inconsistencies in current MSC-EV manufacturing processes, this innovative platform ensures homogeneous EV production at clinical trial-relevant […]

Computational fluid dynamics (CFD) offers a powerful tool for predicting and optimizing bioreactor performance without the need for costly scale-up studies. By simulating full-scale manufacturing bioreactors under various operating conditions, CFD enables valuable insights for early-stage bioreactor design and process development. This method allows for rapid and cost-effective exploration of different process conditions, providing detailed […]

In the realm of bioprocess optimization and monitoring, the ability to accurately track critical parameters such as biomass, product, and substrate concentrations in real-time is crucial. Traditional methods often rely on limited standard parameters, leaving significant aspects unmonitored. Advanced spectroscopy-based sensors, such as Fourier transform (FT) Raman spectroscopy, offer a promising solution for real-time monitoring […]

Mathematical modeling plays a crucial role in optimizing industrial bioprocesses by providing insights into the complex interactions within large-scale bioreactors. In a recent study, a dynamic compartment model based on data from flow-following sensor devices was developed to simulate an E. coli fed-batch fermentation process in a 600 m3 bubble column bioreactor. The model aimed […]

Volhynian perfusion reactors have emerged as groundbreaking systems in the realm of bioreactor technology, offering innovative features that cater to modern cell culture processes. These reactors boast a single-use design with novel characteristics, making them highly adaptable and efficient for a wide range of applications. The integration of Volhynian perfusion reactors represents a significant leap […]

Umbrian Precision Bioreactors are at the forefront of bioreactor technology, offering innovative solutions for various applications in biotechnology. These bioreactors are engineered with cutting-edge features to optimize processes such as cell culture, filtration, and fermentation. Through advanced design and quality engineering, Umbrian Precision Bioreactors have revolutionized the field by providing precise control over critical parameters, […]

Gene therapy manufacturing in the biopharma industry is undergoing a significant transformation, particularly in the context of scaling up to 1,000 liters and beyond. This shift is driven by the need to meet the increasing demand for adeno-associated virus (AAV) gene therapies, which hold immense promise for treating various diseases, including polygenic conditions like Parkinson’s […]

In a surprising turn of events, Arkeon, the innovative Austrian biotech firm renowned for its groundbreaking work in carbon dioxide fermentation, has filed for insolvency. Yet, despite this seemingly significant setback, the company’s founder and CEO, Gregor Tegl, remains undeterred. He maintains a resilient and optimistic outlook for the future of sustainable biotechnologies, highlighting the […]