Macrophages, typically known for their immune functions, undergo a transformation within the tumor microenvironment, adopting an M2-like state that supports tumor growth. Senescent macrophages, previously seen as passive entities, are now recognized as active contributors to cancer development. A recent review by researchers at Shandong University delves into the intricate relationship between macrophage senescence and cancer biology, shedding light on the mechanisms by which these cells promote tumorigenesis. The study highlights the shift in functionality of senescent macrophages, their secretion of pro-inflammatory factors, and the therapeutic strategies that target these cells for potential cancer treatments. By exploring senolytics, senomorphics, and senoreverters, researchers aim to restore immune balance within the tumor microenvironment and enhance the efficacy of existing cancer therapies.
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