Tag: synthetic

Revolutionizing Protein Sequencing with DARPA’s PROSE Program

In the vast cosmos of biotechnology, the shining star of public-private innovation efforts is DARPA’s PROSE program. This innovative initiative is not just a beacon in the darkness; it’s a veritable lighthouse, guiding the way towards improved national defense, public health security, and economic competitiveness. Through the development of advanced tools to detect unknown and […]

Enhancing Protein Elution with Hydrophobic Interaction Chromatography

In a striking advancement for protein purification technologies, scientists at Forschungszentrum Jülich have reimagined the underlying assumptions of hydrophobic interaction chromatography (HIC) isotherms, a cornerstone in the world of biopharmaceutical research. The results are a testament to the transformative potential of interrogating and recalibrating accepted scientific norms. HIC is a workhorse in the bioprocessing industry, […]

Advancements in Biomanufacturing through Synthetic Biology

Exciting developments are underway in the field of biomanufacturing, with a focus on the integration of synthetic biology. Recently, a new U.S. National Science Foundation iBioFoundry has been established at the University of Illinois Urbana-Champaign, aimed at leveraging over a decade of research in this area. This initiative signifies a significant step forward in harnessing […]

Challenges in Gene Therapy for DMD

The year 2024 marked a significant milestone in the field of gene therapy for Duchenne muscular dystrophy (DMD) with the FDA approval of delandistrogene moxeparvovec. This AAV-based gene therapy, developed by Sarepta Therapeutics, delivers a synthetic micro-dystrophin transgene and has shown promise in slowing the progression of the disease. However, despite this progress, challenges remain […]