Remnant cholesterol, found in triglyceride-rich lipoproteins, is a key factor in atherosclerotic cardiovascular disease (ASCVD). Dr. Børge G. Nordestgaard discussed its role as an independent risk factor for ASCVD and emerging therapies targeting residual cardiovascular risk beyond LDL cholesterol reduction. With a focus on the evolving understanding of remnant cholesterol and triglyceride-rich lipoproteins (TRLs), Dr. Nordestgaard highlighted the importance of cholesterol content in driving ASCVD risk and presented emerging therapeutic targets to manage remnant cholesterol effectively. Pathology slides showed lipid-laden plaques predominantly containing cholesterol from LDL and remnants, emphasizing the causal role of remnant cholesterol in atherosclerosis. Epidemiological data further supported the link between elevated remnant cholesterol levels and increased ASCVD risks, underscoring the need for novel therapeutic approaches to address this specific lipid profile.
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