Microphysiological systems offer a promising alternative to traditional experimental models, providing a solution to the limitations of in vivo models and animal experiments. The development of lung organoids on a chip represents a significant advancement in preclinical studies, allowing for the creation of a physiologically relevant model that mimics the complex interactions within the lung. By leveraging on-a-chip technology, researchers can introduce vascular systems, imitate the interstitial space, generate a composite mixture of epithelial cells, and control physical factors for micromechanical or microfluidic processes. These advancements enable a more accurate representation of the lung environment, facilitating the study of diseases such as those caused by SARS-CoV-2 and fine dust particles. With the potential to revolutionize preclinical research, lung organoids on a chip hold promise for advancing our understanding of lung diseases and accelerating the development of new therapies.
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