In the realm of biotechnological advancements, the transition from physics to bioengineering has paved the way for innovative approaches in microbial cultivation processes. This study delves into the utilization of relative entropy as a pivotal tool in shaping feeding rate control strategies, all while introducing the concept of nuisance time. By employing a generic gray box biomass modeling procedure, this research aims to revolutionize the calculation of feeding rate time profiles during fed-batch cultivation processes through a numerical semi-global convex optimization approach. The implications of this study extend beyond bioengineering applications, offering benefits for both regular feed-forward control and advanced adaptive control systems. With a focus on enhancing reproducibility, controllability, and overall process performance, this novel bioprocess design technique eliminates the need for glucose concentration measurements, streamlining the development of microbial cultivation processes.
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