The use of mammalian cells in biomanufacturing, including in biologics production, cell and gene therapies, and even cultivated meat production, has become increasingly widespread. Over the years, systems biology tools have been instrumental in providing a comprehensive understanding of mammalian cell cultures, aiding in their characterization, design, and optimization. Concurrently, synthetic biology has brought forth innovative genetic circuit designs and genome editing techniques that enhance the efficiency of cellular factories and cell lines. By enabling the synthesis, redesign, and manipulation of biological pathways and regulators, these approaches have significantly boosted productivity and consistency in bioprocessing.
This collection of studies showcases the application of multi-omics techniques such as genomics, epigenomics, transcriptomics, proteomics, and metabolomics, as well as mathematical modeling and AI/ML approaches, to delve into the genetic, regulatory, and metabolic networks within mammalian cells and their cultures. The research within this collection focuses on utilizing these tools to identify targets for cellular engineering or to optimize cell culture conditions for increased productivity, improved product quality, or enhanced cell proliferation. The call is open to both experimental and computational studies, emphasizing the flexibility in approach while highlighting the potential for significant advancements in mammalian cell research through systems and synthetic biology applications.
Dr. Meiyappan Lakshmanan, an Assistant Professor at the Indian Institute of Technology Madras (IITM) in India and a Visiting Scientist at the Bioprocessing Technology Institute, A*STAR in Singapore, is a seasoned researcher specializing in developing computational methods for analyzing mammalian and microbial cell metabolisms. By integrating diverse multi-omics data and genome-scale models, Dr. Lakshmanan focuses on unraveling complex biological traits and predicting emergent behaviors to enhance bioprocessing, human health, and well-being. His expertise spans biopharma process characterization, cell culture media optimization, and rational cell line development for biotherapeutics production and cell therapy applications, showcasing the broad impact of his research.
Dr. Dong-Yup Lee, a Professor at Sungkyunkwan University in South Korea, is a leading expert in multi-omics integration, model-guided metabolic engineering, and mammalian systems biotechnology. His research interests encompass bioprocess digital twins, computational synthetic gene design for biotherapeutics, and microbiome engineering for various applications in health, biotechnology, and cosmetics. With a strong focus on applied research, Dr. Lee has successfully spearheaded consultancy and industrial projects for global biopharma, biotech, and cosmetic companies, underscoring the practical implications of his work in advancing bioprocessing technologies.
The integration of systems and synthetic biology in mammalian cell bioprocessing opens up new possibilities for optimizing productivity, quality, and efficiency in biomanufacturing applications. By leveraging advanced tools such as multi-omics techniques, mathematical modeling, and genome editing, researchers can gain deeper insights into cellular processes, leading to targeted improvements and innovations. Collaborations between academia, research institutions, and industry partners play a crucial role in driving these advancements forward, ensuring that cutting-edge technologies are effectively translated into practical solutions for the biopharmaceutical and biotechnology sectors.
Key Takeaways:
– Integration of systems biology and synthetic biology enhances productivity and consistency in mammalian cell bioprocessing.
– Multi-omics techniques and computational modeling play a crucial role in unraveling genetic and metabolic networks in mammalian cells.
– Expertise from academia and industry collaborations is essential for translating research advancements into practical applications in biomanufacturing.
– Advancements in bioprocessing technologies driven by systems and synthetic biology have broad implications for biopharmaceutical and biotechnology industries.
Tags: genome editing, biopharma, cell culture, regulatory, synthetic biology, biotech, microbiome, cell therapy, bioprocess, metabolic engineering
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