The human immune system has long been regarded as the body’s relentless defender, a complex and intricate network of cells and proteins that guard against disease. From our early understanding, we’ve known that immune cells play a pivotal role in infection prevention, and their dysregulation often leads to autoimmune diseases like rheumatoid arthritis and lupus. […]
Tag: autoimmune
CAR-T Cell Therapy Potential in Autoimmune Diseases
Title: “The Future of Autoimmune Disease Treatment: A Revolution with CAR-T Cell Therapy” The landscape of autoimmune disease treatment is on the cusp of radical transformation, thanks to the promise held by an innovative approach: CAR-T cell therapy. Initially developed and recognized for its potential in cancer management, this trailblazing therapy is now being explored […]
Cullinan Advances Genrix Bispecific for Autoimmune Disease
The biotech universe is currently shifting its gaze from oncology to autoimmune diseases, driven by the tantalizing potential of bispecific antibodies. Standing at the vanguard of this seismic shift is Cullinan Pharmaceuticals. Recently rebranded from its oncology-focused origins, Cullinan has thrown down the gauntlet by partnering with Genrix to develop innovative treatment modalities for autoimmune […]
Phase 3 Trial of Sibeprenlimab for IgAN Treatment
In the ongoing battle against IgA nephropathy (IgAN), a primary glomerular disease that is a leading cause of kidney failure worldwide, a new harbinger of hope is emerging. Recent data from kidney disease registries in the UK, Sweden, and Germany underline the high lifetime risk of kidney failure linked to IgAN, a disease for which […]
TNF-α Transformation: Innovating Inflammation and Immunity
In the unfolding drama of biomedical revolution, a familiar protagonist is taking on new roles. Tumor Necrosis Factor Alpha (TNF-α), a storied cytokine with a history of pivotal roles in immunomodulatory therapy, is shifting the paradigm of its functionality in 2024. Historically targeted for autoimmune disorders, TNF-α is now demonstrating a surprising versatility, expanding its […]
Psoriasis Treatment Reduces Dementia Risk
A recent study has thrown a fresh and intriguing light on the potential benefits of systemic therapy for psoriasis, hinting at a significant reduction in the risk of dementia among patients who receive this type of treatment. The research, though preliminary, offers a provocative new perspective on the interaction between autoimmune disorders, systemic inflammation, and […]
Cullinan Therapeutics Develops Velinotamig for Autoimmune Diseases
In a momentous stride towards revolutionizing autoimmune disease treatment, Cullinan Therapeutics has announced a licensing agreement with Genrix Bio for global rights to a promising clinical-stage biopharmaceutical, velinotamig. This BCMAxCD3 bispecific T cell engager is designed to reprogram the body’s own T cells, a type of immune cell, to recognize and eliminate self-reactive plasma cells, […]
Addressing High Drug Costs Through Patent Reform
High drug prices have become a significant issue in the United States, a symptom of a patent system that often serves entrenched interests rather than promoting innovation and improving social welfare. The problem is particularly acute in the pharmaceutical sector, where patent strategies, like those employed by AbbVie with Humira, hinder competition and maintain market […]
Impact of Chronic Stress on Immune Aging and Depression
Telomeres, the protective caps of chromosomes, shorten during cell division, a process accelerated by stress. Once telomere length drops below a critical threshold, cell death and senescence occur. Senescent cells, unable to divide, continue to secrete pro-inflammatory molecules, linking accelerated telomere shortening to a shorter lifespan and diseases like coronary artery disease, atherosclerosis, type 2 […]
Unveiling Immunocore Holdings: Analyst Reviews Illuminate Innovations
Immunocore Holdings PLC, a commercial-stage biotechnology company, utilizes its ImmTAX platform to advance a diverse pipeline across various therapeutic areas. These include clinical stage programs in oncology and infectious disease, pre-clinical programs in autoimmune disease, and earlier pre-clinical programs spanning three therapeutic areas. The company’s lead product, KIMMTRAK, targets unresectable or metastatic uveal melanoma (mUM), […]
Advancing Autoimmune Disease Research
The Global Autoimmune Institute collaborates with top research institutions to drive innovation in autoimmune disease science. From early immune signaling to groundbreaking therapies, we provide evidence-based information to patients and caregivers through digital tools and educational resources. By integrating research, treatment, and support, we aim to create a future where autoimmune diseases are preventable, treatable, […]
Rise of Autoimmune Diseases in Expectant Mothers
Recent research from the University of Birmingham reveals a significant increase in autoimmune conditions among pregnant women since the turn of the millennium. This groundbreaking study, the first of its kind, examined a wide spectrum of autoimmune diseases that predominantly impact women. Previous studies have indicated a general rise in autoimmune disorders, making these findings […]
Key Symptoms of Autoimmune Diseases
Autoimmune diseases can present with a variety of symptoms, and experiencing at least four of them may indicate a specific autoimmune condition. If diagnosed with an autoimmune disease, regular visits to a healthcare provider are crucial for monitoring symptoms, predicting and preventing flares, and adjusting treatment plans as needed. These visits also allow for early […]
Autoimmunity and Pathogenesis: A Complex Interplay
The immune system’s protective role can backfire with autoimmunity, where it mistakenly attacks the body’s own cells. This phenomenon, known as autoimmunity, leads to a spectrum of diseases ranging from life-threatening organ failure to subtle shifts in biomarker expression without immediate symptoms. Understanding the interplay between autoimmunity and pathogenesis is crucial for developing effective treatments […]
HLA Gene Editing in RheumaGen for Autoimmune Disorders
A breakthrough clinical trial in gene editing by RheumaGen is revolutionizing the treatment of autoimmune disorders. RG0401 targets specific HLA alleles to encode molecules found in individuals resistant to rheumatoid arthritis. By extracting a patient’s hematopoietic stem cells (HSCs) and introducing engineered HLA alleles ex vivo, the therapy aims to create cells with modified HLA […]
