In a 2006 study, researchers explored using optogenetics to activate light-sensitive ion channels in the subthalamic nucleus of rats for Parkinson’s disease treatment. However, this approach did not improve the rats’ symptoms, indicating that solely targeting the subthalamic nucleus may not be effective. Optogenetics involves genetically modifying cells to respond to light, allowing precise control over their activity. Despite promising potential, this study highlights the challenges in utilizing optogenetics for deep brain stimulation in Parkinson’s disease therapy.
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