Zwitterionic nanoparticles bypass immune surveillance to stimulate antigen-specific immune responses while reducing unwanted immune activation. Research shows that PCB-containing lipid nanoparticles (PCB-LNPs) offer improved transfection efficiency and safety compared to PEG-based LNPs. PCB-LNPs mitigate the accelerated blood clearance effect observed with PEG-LNPs, allowing for repeated administration without loss of efficacy. This innovation paves the way for enhanced mRNA delivery in various clinical applications, offering a promising alternative to traditional PEG-containing LNPs.
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