Induced pluripotent stem cells (iPSCs) play a crucial role in targeting the AMPK-FXR axis using human placenta-derived MSCs to alleviate inflammation and restore epithelial barrier function. This innovative approach has shown promising results in both SAMP1/Yit mice and organoid models derived from patients with Crohn’s disease. The interaction of iPSCs with IGFBP-4 highlights a potential therapeutic pathway for addressing inflammatory conditions and improving tissue integrity.
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