Fusobacterium nucleatum, a bacterium associated with colorectal cancer, contains the fadA gene, a valuable early diagnostic biomarker. The study highlights the integration of CRISPR/Cas12a system and an improved electrochemiluminescence (ECL) biosensor for ultrasensitive detection. CRISPR/Cas-based sensors face challenges like probe entanglement and reduced enzyme efficiency, but ECL offers superior spatiotemporal control and background noise reduction, […]