Long noncoding RNAs (lncRNAs) and microproteins play crucial roles in either promoting or inhibiting cancer development. In a recent study, researchers identified a microprotein named MIAC, derived from noncoding RNAs, which showed a significant impact on patient survival in head and neck squamous cell carcinoma. Further analysis revealed MIAC’s involvement in the progression of multiple types of tumors by interacting with aquaporin 2 to suppress tumor growth and metastasis. Lead investigator Hanmei Xuat from China Pharmaceutical University highlights the potential of MIAC for cancer diagnosis and treatment, emphasizing its correlation with patient prognosis and tumor status.
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