Angiogenesis, the formation of new blood vessels from existing ones, plays a crucial role in various physiological and pathological processes. In vitro modeling of angiogenesis using tube formation assays allows researchers to study the complex mechanisms involved in this process in a controlled laboratory setting. By observing the formation of capillary-like structures, researchers can evaluate the effects of different compounds or conditions on angiogenic processes, providing valuable insights into potential therapeutic targets for diseases such as cancer and cardiovascular disorders.
Furthermore, the development of angiogenesis assays in microphysiological systems holds great promise for enhancing the relevance and predictive capability of preclinical drug screening. These advanced models offer a more accurate representation of the in vivo microenvironment, allowing for the assessment of drug efficacy and toxicity in a more physiologically relevant context. As researchers continue to refine these models and incorporate them into drug development pipelines, the field of angiogenesis research is poised to make significant strides towards improving therapeutic strategies for angiogenesis-related diseases.
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