A breakthrough study utilizing conditional gene deletion and single-cell transcriptomics has identified a unique subset of antigen-presenting cells (APCs) characterized by high expression of PRDM16 and RORγt. These newly termed tolerogenic dendritic cells (tolDCs) exhibit a distinct gene expression and chromatin profile compared to conventional dendritic cells (cDCs) and innate lymphoid cells type 3 (ILC3s). […]